References

Studies, References, and Citations for specific ingredients in our products.

DIM (Diindolylmethane)

  1. Riby JE1, et al. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway. Biochemistry. (2000)
  2. Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane.
  3. Marques M, et al. Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation in the absence of estradiol. BMC Cancer. (2014)
  4. Lo R, Matthews J. A new class of estrogen receptor beta-selective activators. Mol Interv. (2010)
  5. Song L, Thornalley PJ. Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables. Food Chem Toxicol. (2007)
  6. Chang HP, et al. Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice. Nutrition. (2011)
  7. Bradfield CA, Bjeldanes LF. Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. J Toxicol Environ Health. (1987)
  8. McNaughton SA, Marks GC. Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables. Br J Nutr. (2003)
  9. Verkerk R, Dekker M. Glucosinolates and myrosinase activity in red cabbage (Brassica oleracea L. var. Capitata f. rubra DC.) after various microwave treatments.J Agric Food Chem. (2004)
  10. Leong H1, et al. Potent ligand-independent estrogen receptor activation by 3,3′-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Mol Endocrinol. (2004)
  11. Leong H1, Firestone GL, Bjeldanes LF. Cytostatic effects of 3,3′-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression. Carcinogenesis. (2001)
  12. Sepkovic DW, et al. Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or beta-naphthaflavone: a comparison of stable isotope dilution gas chromatography-mass spectrometry and radiometric methods. Steroids. (1994)
  13. Bradlow HL, et al. 2-hydroxyestrone: the ‘good’ estrogen. J Endocrinol. (1996)

Rhodiola Rosea

  1. Colson SN, et al. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res. (2005)
  2. Earnest CP, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. (2004)
  3. Skarpanska-Stejnborn A, et al. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc Metab. (2009)
  4. Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol. (2000)
  5. Rohloff J. Volatiles from rhizomes of Rhodiola rosea L. Phytochemistry. (2002)
  6. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. (2010)
  7. Jafari M, et al. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res. (2007)
  8. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their Stress – Protective Activity.
  9. Mudge E, et al. Purification of Phenylalkanoids and monoterpene glycosides from rhodiola rosea L. roots by high-speed counter-current chromatography.Phytochem Anal. (2013)
  10. Akgul Y, et al. Lotaustralin from Rhodiola rosea roots. Fitoterapia. (2004)
  11. Partridge L, Gems D. Mechanisms of ageing: public or private. Nat Rev Genet. (2002)
  12. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. (2009)
  13. Petkov VD, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg. (1986)
  14. Cifani C, et al. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating. Physiol Behav. (2010)
  15. Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol. (2007)
  16. Micioni Di Bonaventura MV, et al. Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats. J Obes. (2012)
  17. Cifani C, et al. A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam. Psychopharmacology (Berl). (2009)
  18. Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice.Phytother Res. (2007)
  19. Li HB, et al. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol. (2008)
  20. Parisi A, et al. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness. (2010)
  21. Walker TB, et al. Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men. Metabolism. (2007)
  22. Noreen EE, et al. The Effects of an Acute Dose of Rhodiola Rosea on Endurance Exercise Performance. J Strength Cond Res. (2012)

Vitamin B6

  1. Zemel MB1, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects. Nutrients. (2012)
  2. Clayton PT. B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis. (2006)
  3. Allgood VE1, Cidlowski JA. Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily. J Biol Chem. (1992)
  4. Nelson EW Jr, Lane H, Cerda JJ. Comparative human intestinal bioavailability of vitamin B-6 from a synthetic and a natural source. J Nutr. (1976)
  5. Delitala G, et al. Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway. J Clin Endocrinol Metab. (1976)
  6. Allen GF1, et al. Pyridoxal 5′-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states. J Neurochem. (2010)
  7. Allgood VE1, Powell-Oliver FE, Cidlowski JA. The influence of vitamin B6 on the structure and function of the glucocorticoid receptor. Ann N Y Acad Sci. (1990)
  8. Allgood VE1, Powell-Oliver FE, Cidlowski JA. Vitamin B6 influences glucocorticoid receptor-dependent gene expression. J Biol Chem. (1990)
  9. Moretti C, et al. Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. N Engl J Med. (1982)
  10. Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl. (1981)

ZMA (Zinc Magnesium)

  1. De Souza MC, et al. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. (2000)

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