Studies, References, and Citations for specific ingredients in our products.

DIM (Diindolylmethane)

  1. Riby JE1, et al. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathwayBiochemistry. (2000)
  2. Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane.
  3. Marques M, et al. Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation in the absence of estradiolBMC Cancer. (2014)
  4. Lo R, Matthews J. A new class of estrogen receptor beta-selective activatorsMol Interv. (2010)
  5. Song L, Thornalley PJ. Effect of storage, processing and cooking on glucosinolate content of Brassica vegetablesFood Chem Toxicol. (2007)
  6. Chang HP, et al. Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese miceNutrition. (2011)
  7. Bradfield CA, Bjeldanes LF. Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolismJ Toxicol Environ Health. (1987)
  8. McNaughton SA, Marks GC. Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetablesBr J Nutr. (2003)
  9. Verkerk R, Dekker M. Glucosinolates and myrosinase activity in red cabbage (Brassica oleracea L. var. Capitata f. rubra DC.) after various microwave treatments.J Agric Food Chem. (2004)
  10. Leong H1, et al. Potent ligand-independent estrogen receptor activation by 3,3′-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathwaysMol Endocrinol. (2004)
  11. Leong H1, Firestone GL, Bjeldanes LF. Cytostatic effects of 3,3′-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expressionCarcinogenesis. (2001)
  12. Sepkovic DW, et al. Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or beta-naphthaflavone: a comparison of stable isotope dilution gas chromatography-mass spectrometry and radiometric methodsSteroids. (1994)
  13. Bradlow HL, et al. 2-hydroxyestrone: the ‘good’ estrogenJ Endocrinol. (1996)

Rhodiola Rosea

  1. Colson SN, et al. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturationJ Strength Cond Res. (2005)
  2. Earnest CP, et al. Effects of a commercial herbal-based formula on exercise performance in cyclistsMed Sci Sports Exerc. (2004)
  3. Skarpanska-Stejnborn A, et al. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowersInt J Sport Nutr Exerc Metab. (2009)
  4. Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic loadEksp Klin Farmakol. (2000)
  5. Rohloff J. Volatiles from rhizomes of Rhodiola rosea LPhytochemistry. (2002)
  6. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacyPhytomedicine. (2010)
  7. Jafari M, et al. Rhodiola: a promising anti-aging Chinese herbRejuvenation Res. (2007)
  8. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their Stress – Protective Activity.
  9. Mudge E, et al. Purification of Phenylalkanoids and monoterpene glycosides from rhodiola rosea L. roots by high-speed counter-current chromatography.Phytochem Anal. (2013)
  10. Akgul Y, et al. Lotaustralin from Rhodiola rosea rootsFitoterapia. (2004)
  11. Partridge L, Gems D. Mechanisms of ageing: public or privateNat Rev Genet. (2002)
  12. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activityCurr Clin Pharmacol. (2009)
  13. Petkov VD, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memoryActa Physiol Pharmacol Bulg. (1986)
  14. Cifani C, et al. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eatingPhysiol Behav. (2010)
  15. Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in ratsJ Psychopharmacol. (2007)
  16. Micioni Di Bonaventura MV, et al. Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female RatsJ Obes. (2012)
  17. Cifani C, et al. A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolamPsychopharmacology (Berl). (2009)
  18. Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice.Phytother Res. (2007)
  19. Li HB, et al. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinaseEur J Pharmacol. (2008)
  20. Parisi A, et al. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary resultsJ Sports Med Phys Fitness. (2010)
  21. Walker TB, et al. Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained menMetabolism. (2007)
  22. Noreen EE, et al. The Effects of an Acute Dose of Rhodiola Rosea on Endurance Exercise PerformanceJ Strength Cond Res. (2012)

Vitamin B6

  1. Zemel MB1, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjectsNutrients. (2012)
  2. Clayton PT. B6-responsive disorders: a model of vitamin dependencyJ Inherit Metab Dis. (2006)
  3. Allgood VE1, Cidlowski JA. Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamilyJ Biol Chem. (1992)
  4. Nelson EW Jr, Lane H, Cerda JJ. Comparative human intestinal bioavailability of vitamin B-6 from a synthetic and a natural sourceJ Nutr. (1976)
  5. Delitala G, et al. Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathwayJ Clin Endocrinol Metab. (1976)
  6. Allen GF1, et al. Pyridoxal 5′-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency statesJ Neurochem. (2010)
  7. Allgood VE1, Powell-Oliver FE, Cidlowski JA. The influence of vitamin B6 on the structure and function of the glucocorticoid receptorAnn N Y Acad Sci. (1990)
  8. Allgood VE1, Powell-Oliver FE, Cidlowski JA. Vitamin B6 influences glucocorticoid receptor-dependent gene expressionJ Biol Chem. (1990)
  9. Moretti C, et al. Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exerciseN Engl J Med. (1982)
  10. Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm countArch Androl. (1981)

ZMA (Zinc Magnesium)

  1. De Souza MC, et al. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover studyJ Womens Health Gend Based Med. (2000)



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